abstract：BACKGROUND/AIMS:Phase I/II studies of 4 weeks duration have confirmed the ALT lowering effect of glycyrrhizin in Western chronic hepatitis C patients. Our aim was to determine the dose frequency of glycyrrhizin required to maintain the ALT response beyond 4 weeks and evaluate its effect on liver histology and quality o...

journal_title：Journal of hepatology

authors： Orlent H,Hansen BE,Willems M,Brouwer JT,Huber R,Kullak-Ublick GA,Gerken G,Zeuzem S,Nevens F,Tielemans WC,Zondervan PE,Lagging M,Westin J,Schalm SW

更新日期：2006-10-01 00:00:00

abstract：BACKGROUND/AIMS:Interleukin-15 (IL-15) is expressed in many organs. It generally inhibits apoptosis and increases cellular proliferation and differentiation. However, IL-15's roles in liver are unknown. We aimed to determine if IL-15 influences hepatic integrity and regenerative activity. METHODS:Expression of IL-15 a...

journal_title：Journal of hepatology

authors： Suzuki A,McCall S,Choi SS,Sicklick JK,Huang J,Qi Y,Zdanowicz M,Camp T,Li YX,Diehl AM

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND/AIMS:Hepatic stellate cells (HSCs) play a key role in hepatic fibrogenesis. However, their origin is still unknown. We tested the hypothesis that bone marrow (BM) contributes to the population of HSCs. METHODS:Chimeric mice transplanted with donor BM from collagen alpha1(I)-GFP+ reporter mice were subjected...

journal_title：Journal of hepatology

authors： Kisseleva T,Uchinami H,Feirt N,Quintana-Bustamante O,Segovia JC,Schwabe RF,Brenner DA

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND/AIMS:Results of our previous studies supported the concept that in the human liver, the smallest ramification of the biliary tree, the bile ductules, might contain hepatic progenitor cells. An insufficient proliferative response and loss of bile ductules preceded bile duct loss whereas preservation of bile d...

journal_title：Journal of hepatology

authors： Gouw AS,van den Heuvel MC,Boot M,Slooff MJ,Poppema S,de Jong KP

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND/AIMS:Periodic endoscopic screening for oesophageal varices is recommended in patients with cirrhosis, but might be limited to a subgroup of patients if a simple non-invasive test was available to select those at risk of bleeding. METHODS:We studied in 165 patients with cirrhosis the relation between the pre...

journal_title：Journal of hepatology

authors： Kazemi F,Kettaneh A,N'kontchou G,Pinto E,Ganne-Carrie N,Trinchet JC,Beaugrand M

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND/AIMS:ATP stimulation of purinergic P2 receptors (P2YR and P2XR) regulates several hepatic functions. Here we report the involvement of ATP-mediated signals in enhancing hepatocyte tolerance to lethal stress. METHODS:The protection given by purinergic agonists was investigated in rat hepatocytes exposed to h...

journal_title：Journal of hepatology

authors： Carini R,Alchera E,De Cesaris MG,Splendore R,Piranda D,Baldanzi G,Albano E

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND/AIMS:We tested whether cholesterol gallstone disease (GS) is associated to insulin resistance and serum C-reactive protein (CRP) in a high risk population. METHODS:This was a nested case-control study on 881 Chilean subjects that included clinical examination, abdominal ultrasound and blood chemistries. Ins...

journal_title：Journal of hepatology

authors： Nervi F,Miquel JF,Alvarez M,Ferreccio C,García-Zattera MJ,González R,Pérez-Ayuso RM,Rigotti A,Villarroel L

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND/AIMS:Fulminant hepatic failure (FHF) can be dreadful. When coma sets in, brain edema develops taking FHF into a lethal course. Mechanisms of brain extravasation leading to brain edema remain incompletely understood. Matrix metalloproteinase (MMP)-9 is implicated in various brain injuries. We hypothesized tha...

journal_title：Journal of hepatology

authors： Nguyen JH,Yamamoto S,Steers J,Sevlever D,Lin W,Shimojima N,Castanedes-Casey M,Genco P,Golde T,Richelson E,Dickson D,McKinney M,Eckman CB

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND/AIMS:The factors which predict the long-term outcome in patients with hepatocellular carcinoma who are treated with percutaneous laser ablation (PLA) are not well established. METHODS:We prospectively analyzed treatment and survival parameters of 148 cirrhotic patients with nonsurgical hepatocellular carcin...

journal_title：Journal of hepatology

authors： Pacella CM,Bizzarri G,Francica G,Forlini G,Petrolati A,Valle D,Anelli V,Bianchini A,Nuntis SD,Pacella S,Rossi Z,Osborn J,Stasi R

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND/AIMS:Leptin has a particular profibrogenic role in the liver. We investigated whether IFN-alpha influences leptin production in patients with chronic hepatitis B (CHB) and C (CHC). Leptin was determined in serial samples from 63 CHB and 42 CHC IFN-alpha treated patients. Furthermore, we evaluated whether lep...

journal_title：Journal of hepatology

authors： Zografos TA,Rigopoulou EI,Liaskos C,Togousidis E,Zachou K,Gatselis N,Germenis A,Dalekos GN

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND/AIMS:The finer branches of the biliary tree play an important role in biliary regeneration. They are consistently escorted by microvessels. Defects in the vascularization of these structures could impair bile duct regeneration. Therefore, we investigated the pattern of the escorting microvessels during the d...

journal_title：Journal of hepatology

authors： van den Heuvel MC,Gouw AS,Boot M,Slooff MJ,Poppema S,de Jong KP

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND/AIMS:In chronic hepatitis C, disease progression and clinical manifestations are heterogenous. To clarify the role and interactions of viral and host factors in inducing liver cell injury, we examined the associations of several virological and metabolic variables with serum alanine aminotransferase levels. ...

journal_title：Journal of hepatology

authors： Prati D,Shiffman ML,Diago M,Gane E,Rajender Reddy K,Pockros P,Farci P,O'Brien CB,Lardelli P,Blotner S,Zeuzem S

更新日期：2006-04-01 00:00:00

abstract：BACKGROUND/AIMS:The administration of a methionine and choline deficient (MCD) diet to mice serves as an animal model of NASH. The multidrug resistant 2 (Mdr2) P-glycoprotein encodes for the canalicular phospholipid transporter, and Mdr2 (+/-) mice secrete 40% less phosphatidylcholine than wild-type mice. We have hypot...

journal_title：Journal of hepatology

authors： Igolnikov AC,Green RM

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND/AIMS:Liver negative-strand hepatitis C virus (HCV) RNA is the most direct indicator of active viral replication but has only been examined in a few semiquantitative studies. METHODS:Positive- and negative-strand HCV RNA in the right (R) and left (L) liver lobes was quantified by rTth-based strand-specific r...

journal_title：Journal of hepatology

authors： Yuki N,Matsumoto S,Tadokoro K,Mochizuki K,Kato M,Yamaguchi T

更新日期：2006-02-01 00:00:00

abstract：BACKGROUND/AIMS:We developed a bioartificial liver (BAL) based on a direct hemoperfusion typed nonwoven fabric bioreactor containing porcine hepatocytes. In this study, the efficacy of our BAL was evaluated with a pig fulminant hepatic failure (FHF) model. METHODS:FHF was induced with intravenous administration of D-g...

journal_title：Journal of hepatology

authors： Li LJ,Du WB,Zhang YM,Li J,Pan XP,Chen JJ,Cao HC,Chen Y,Chen YM

更新日期：2006-02-01 00:00:00

abstract：:We describe a PFIC2 patient with a good response to ursodeoxycholic acid for 9 years. We found two novel ABCB11 gene mutations in the patient, i.e. I498T and 2098delA. The correlation of the patient's genotypes with the clinical course supports the existence of a phenotypic continuum between BRIC2 and PFIC2. ...

journal_title：Journal of hepatology

authors： Lam CW,Cheung KM,Tsui MS,Yan MS,Lee CY,Tong SF

更新日期：2006-01-01 00:00:00

abstract：:The First European Consensus Conference on the Treatment of Chronic Hepatitis B and C in HIV Co-infected Patients aimed to produce recommendations that could be applied across Europe. However, some important differences exist around Europe, in terms of access to treatment and tests for monitoring. This short survey of...

journal_title：Journal of hepatology

authors： Salmon D,Robain M,Rockstroh JK,Benhamou Y

更新日期：2006-01-01 00:00:00

abstract：:The natural history of HBV is known to be complicated by HIV-co-infection. In contrast, the effect of HBV on the outcome of patients infected with HIV-1 is controversial. Some cohort studies from the pre-HAART era described a more rapid progression to AIDS in patients carrying antibodies to the core-antigen or having ...

journal_title：Journal of hepatology

authors： Rockstroh JK

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND/AIMS:In 2002, the first reported outbreak of hepatitis A virus (HAV) infection involving mostly intravenous drug users (IDU) occurred in Italy. We attempted a thorough evaluation of the outbreak, including epidemiological, clinical and virological analyses. METHODS:We conducted an epidemiological investigat...

journal_title：Journal of hepatology

authors： Spada E,Genovese D,Tosti ME,Mariano A,Cuccuini M,Proietti L,Giuli CD,Lavagna A,Crapa GE,Morace G,Taffon S,Mele A,Rezza G,Rapicetta M

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND/AIMS:This study evaluates the agreement between reported use of interventions for patients with liver diseases and research evidence in Cochrane systematic reviews. METHODS:In July 2002, the Cochrane Hepato-Biliary Group had completed 28 systematic reviews on 36 interventions that were available in Denmark....

journal_title：Journal of hepatology

authors： Kürstein P,Gluud LL,Willemann M,Olsen KR,Kjellberg J,Sogaard J,Gluud C

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND/AIMS:Suppressor of cytokine signaling (SOCS)-1, a negative feedback regulator of cytokine signaling pathway, also has a tumor suppressor activity, the silencing of its gene by hypermethylation is suggested to contribute to hepatocarcinogenesis. We studied the effect of the core protein of hepatitis C virus (...

journal_title：Journal of hepatology

authors： Miyoshi H,Fujie H,Shintani Y,Tsutsumi T,Shinzawa S,Makuuchi M,Kokudo N,Matsuura Y,Suzuki T,Miyamura T,Moriya K,Koike K

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND/AIMS:Local ablation methods are an effective treatment for hepatocellular carcinoma (HCC). The rate of recurrence or development of intra-hepatic metastases may be lowered by antitumoral immune responses. Since HCCs are in general only weakly immunogenic, cell injury induced by local tumor ablation (PEI/RFTA...

journal_title：Journal of hepatology

authors： Ali MY,Grimm CF,Ritter M,Mohr L,Allgaier HP,Weth R,Bocher WO,Endrulat K,Blum HE,Geissler M

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND/AIMS:We conducted an analysis of chromosomal numerical aberrations and their clinical significance in hepatocellular carcinoma. METHODS:We analyzed 87 hepatocellular carcinomas by array-based comparative genomic hybridization with an array containing 800 bacterial artificial chromosome clones. RESULTS:Freq...

journal_title：Journal of hepatology

authors： Katoh H,Shibata T,Kokubu A,Ojima H,Loukopoulos P,Kanai Y,Kosuge T,Fukayama M,Kondo T,Sakamoto M,Hosoda F,Ohki M,Imoto I,Inazawa J,Hirohashi S

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND/AIMS:The hepatocyte receptor for asialoglycoproteins internalizes galactosyl terminating macromolecules which can be used as hepatotropic drug carriers. Since this receptor is also expressed on the cells of well differentiated human hepatocellular carcinomas (HCCs), we studied whether conjugation of doxorubi...

journal_title：Journal of hepatology

authors： Fiume L,Bolondi L,Busi C,Chieco P,Kratz F,Lanza M,Mattioli A,Di Stefano G

更新日期：2005-10-01 00:00:00

abstract：BACKGROUND/AIMS:Hepcidin is a liver-expressed peptide which plays an important role in the regulation of iron metabolism. It is a negative regulator of iron absorption and release of iron from cells. The aims of this study were to analyse the expression and localisation of prohepcidin in liver and cell lines. METHODS:...

journal_title：Journal of hepatology

authors： Wallace DF,Summerville L,Lusby PE,Subramaniam VN

更新日期：2005-10-01 00:00:00

abstract：BACKGROUND/AIMS:We reported massive liver repopulation by transplanted hepatocytes in rats given retrorsine (RS), a pyrrolizidine alkaloid which blocks proliferation of resident cells. In these studies, molecular alterations induced by RS on hepatocyte cell cycle were investigated. METHODS:Animals were treated accordi...

journal_title：Journal of hepatology

authors： Pitzalis S,Doratiotto S,Greco M,Montisci S,Pasciu D,Porcu G,Pani P,Laconi S,Laconi E

更新日期：2005-09-01 00:00:00

abstract：BACKGROUND/AIMS:Little is known about the nucleotide excision repair (NER) pathway in the resistance of human hepatocellular carcinoma (HCC) to chemotherapeutics. We investigated expression of several NER genes in human HCC and matching non-tumor tissue (NT) and in normal liver. METHODS:Expression of CSA, CSB, XPC, hH...

journal_title：Journal of hepatology

authors： Fautrel A,Andrieux L,Musso O,Boudjema K,Guillouzo A,Langouët S

更新日期：2005-08-01 00:00:00

abstract：BACKGROUND/AIMS:Although 6-thioguanine (6-TG) has been suggested as an effective treatment option for patients with inflammatory bowel disease (IBD), the recent description of its hepatotoxicity has led to the recommendation not to consider this drug. We initiated a multicenter safety study in IBD-patients treated with...

journal_title：Journal of hepatology

authors： Seiderer J,Zech CJ,Reinisch W,Lukas M,Diebold J,Wrba F,Teml A,Chalupna P,Stritesky J,Schoenberg SO,Schima W,Göke B,Ochsenkühn T

更新日期：2005-08-01 00:00:00

abstract：BACKGROUND/AIMS:Ascites in patients with cirrhosis is associated with worsening of systemic hemodynamics. Thus, the aim of this study was to investigate the biological activity of ascites on endothelial cells. METHODS:Human umbilical vein endothelial cells (HUVECs) were used to investigate the angiogenic activity of a...

journal_title：Journal of hepatology

authors： Morales-Ruiz M,Tugues S,Cejudo-Martín P,Ros J,Melgar-Lesmes P,Fernández-Llama P,Arroyo V,Rodés J,Jiménez W

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND/AIMS:The applicability of adult-to-adult living donor liver transplantation has not been established yet. We report the first data in a European center of the process leading to this procedure from the first moment the patients were informed about it. METHODS:In phase 1 of the process, 121 adult patients en...

journal_title：Journal of hepatology

authors： Rimola A,Llovet JM,Navasa M,Bruix J,Londoño MC,Fuster J,García-Valdecasas JC

更新日期：2005-07-01 00:00:00

abstract：:Familial hypobetalipoproteinemia (FHBL) is an monogenic co-dominant disorder characterized by reduced plasma levels of cholesterol, low density lipoproteins (LDL) and apolipoprotein B (apoB) often associated with non-alcoholic fatty liver disease (NAFLD). It has been suggested that FHBL might predispose to gallstone d...

journal_title：Journal of hepatology

authors： Lancellotti S,Zaffanello M,Di Leo E,Costa L,Lonardo A,Tarugi P

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND/AIMS:Hepatitis B virus (HBV) infection in extrahepatic tissues is controversial. To clarify whether episomal HBV can infect nonhepatic tissues, we investigated the molecular forms of HBV in the lymphatic cells of inactive HBV carriers who lacked viremia, thus avoiding contamination with HBV genomes originati...

journal_title：Journal of hepatology

authors： Umeda M,Marusawa H,Seno H,Katsurada A,Nabeshima M,Egawa H,Uemoto S,Inomata Y,Tanaka K,Chiba T

更新日期：2005-06-01 00:00:00

abstract：BACKGROUND/AIMS:Hepatic stellate cells are pivotal to fibrogenesis in the liver and many potential anti-fibrotic therapeutics are required to act on targets within hepatic stellate cells. The aim of this study was to generate a human antibody fragment to hepatic stellate cells. METHODS:Phage display was used to genera...

journal_title：Journal of hepatology

authors： Elrick LJ,Leel V,Blaylock MG,Duncan L,Drever MR,Strachan G,Charlton KA,Koruth M,Porter AJ,Wright MC

更新日期：2005-06-01 00:00:00

abstract：:Drug induced hepatotoxicity has been reported infrequently with sulfonylureas. For glimepiride, a second-generation sulfonylurea there is no report of hepatotoxicity in English literature. A patient with non-insulin-dependent diabetes mellitus who developed cholestatic liver injury soon after initiation of glimepiride...

journal_title：Journal of hepatology

authors： Chounta A,Zouridakis S,Ellinas C,Tsiodras S,Zoumpouli C,Kopanakis S,Giamarellou H

更新日期：2005-06-01 00:00:00

abstract：BACKGROUND/AIMS:The aim of this study is to verify the efficacy and safety of peg-interferon alfa-2b in combination with ribavirin for initial treatment of HCV-associated mixed cryoglobulinemia. METHODS:Eighteen patients (7 women and 11 men) affected by mixed cryoglobulinemia were included in the study and treated wit...

journal_title：Journal of hepatology

authors： Mazzaro C,Zorat F,Caizzi M,Donada C,Di Gennaro G,Maso LD,Carniello G,Virgolini L,Tirelli U,Pozzato G

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND/AIMS:The aim of the present study was to compare MELD score, Child-Turcotte-Pugh (CTP) score, modified Maddrey's Discriminant Function (DF) score, and the related variables in predicting in-hospital mortality of patients with alcoholic hepatitis. METHODS:A retrospective chart review and statistical analyses...

journal_title：Journal of hepatology

authors： Srikureja W,Kyulo NL,Runyon BA,Hu KQ

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND/AIMS:To bridge acute liver failure (ALF) patients to orthotopic liver transplantation, several bioartificial liver (BAL) systems have been developed. The bio-component of most BAL systems consists mainly of porcine hepatocytes. Plasma or blood of ALF patients is perfused through the BAL thereby contacting po...

journal_title：Journal of hepatology

authors： van de Kerkhove MP,Germans MR,Deurholt T,Hoekstra R,Joziasse DH,van Wijk AC,van Gulik TM,Chamuleau RA,Roos A

更新日期：2005-04-01 00:00:00

abstract：:Porphyria cutanea tarda (PCT) is a metabolic disorder characterized by a reduced hepatic activity of uroporphynogen decarboxylase (URO-D), an enzyme of the heme synthesis. The clinical features of PCT may be brought into light by hepatic injury induced by hepatitis C virus (HCV). A significant association between HCV ...

journal_title：Journal of hepatology

authors： Thevenot T,Bachmeyer C,Hammi R,Dumouchel P,Ducamp-Posak I,Cadranel JF

更新日期：2005-04-01 00:00:00

abstract：BACKGROUND/AIMS:The pathophysiology of binge drinking of ethanol and its potentiation of acetaminophen (APAP) toxicity has received very little attention. To evaluate if ethanol binging sensitizes hepatic sinusoidal endothelial cells (SEC) and liver to APAP toxicity. METHODS:The histopathological responses to APAP wer...

journal_title：Journal of hepatology

authors： McCuskey RS,Bethea NW,Wong J,McCuskey MK,Abril ER,Wang X,Ito Y,DeLeve LD

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND/AIMS:Hepatic undifferentiated (embryonal) sarcoma (HUS) is an exceptional hepatic malignant tumor in adults. Genetic studies were never reported in adult cases. METHODS:In this study concerning three cases of HUS occurring in adult, we studied the three classical ways of carcinogenesis i.e. the TP53 (p53), ...

journal_title：Journal of hepatology

authors： Lepreux S,Rebouissou S,Le Bail B,Saric J,Balabaud C,Bloch B,Martin-Négrier ML,Zucman-Rossi J,Bioulac-Sage P

更新日期：2005-03-01 00:00:00